The Sanford Stakes is an American Thoroughbred horse race held annually during the third week of July at the Saratoga Race Course in Saratoga Springs, New York. A six furlong sprint race, the Grade II event is open to two-year-old horses.

Inaugurated in 1913 as the Sanford Memorial Stakes, it was modified to its present name in 1927. The race is named for Stephen Sanford and his son John, Amsterdam, New York businessmen from one of Saratoga's original horse racing families. Their horses first appeared in the Saratoga races in 1880. Stephen Sanford named all his best horses after members of the Mohawk nation.

The race was hosted by Belmont Park from 1943 through 1945. It was contested at five and a half furlongs from 1962 through 1968. Held for almost a hundred years, the only two years in which it did not take place was 1961 and 2005. Only four horses have ever won all three Saratoga Racecourse events for two-year-olds. Regret (1914), Campfire (1916), Dehere (1993), and City Zip (2000) each swept the Sanford Stakes, Saratoga Special Stakes, and Hopeful Stakes.

It was in the seventh running of the Sanford in 1919 that the great Man o' War lost his only race to a horse called Upset.