The Tokyo City Cup Handicap is an American Thoroughbred horse race run annually, typically at the end of March, at Santa Anita Park in Arcadia, California. A Grade III event raced on dirt at a distance of 1 1/2 miles (12 furlongs), it is open to horses aged four and older.

Run as the San Bernardino Handicap prior to 2005, the races name honors the partnership between Santa Anita Park and Ohi Racecourse in Tokyo, Japan. The race was open to three-year-olds only in 1957 and for three-year-olds and up from 1958 through 1967. Raced on dirt at 1 1/16 miles from 1957 through 1966 and on turf at 1 1/8 miles from 1967 through 1972 and 1974 through 1978. Since inception it has been contested at various distances and on both dirt and turf. The Tokyo City Cup was run in two divisions in 1971 and again in 1974.